Capter 11 Biotechnology Drug Products

Chapter11 今日のメモ☆

バイオテクノロジーで活用する医療単語の説明と、バイオテクノロジーから生まれた薬などの紹介。

Miscellaneous Biotechnologic product
 - Alteplase
    thrombolytic agent（血栓溶解剤） known as tissue-plasminogen activator
    recanalization of occluded coronary arteris after acute myocardinal infarction（心筋梗塞） & acute massive pulmonary embolism（肺動脈塞栓）
    side effect : bleeding, reperfusion arrhythmias（不整脈）, reinfarction

 - Antithrombin III (heparin cofactor)
    therapy to prevent or treat thromboembolic episodes in antithrombin III deficiency

- IL-3
    hematopoietic growth factor
    treat patients with bone marrow failure (chemotherapy-related bone marrow failure,  myelodysplastic syndrome（骨髄異形成症候群） etc)

 - Aldesleukin (hrIL-2)
    treat metastatic renal cell carcinoma（転移性腎癌）
    side effect (dose-related) : hypotension , flulike synptoms

 - Abciximab (chimeric monoclonal antibody)
    unstable angina（狭心症） after they undergo angioplasty（血管形成術）
    side effect (dose-related) : bleeding

 - Campath-1 (MAb)
    immunosuppression for organ transplant (prevent graft-versus-host disease & lymphoid malignancy（リンパ性悪性疾患)
    refractory autoimmune disorders(rheumatoid arthritis), treat vasculitis（血管炎）

 - Satumomab pendetide (MAb)
    used as a diagnostic imagin agent for colorectal（直腸）and ovarian（卵巣） carcinoma

 - Edobacomab, Nebacumab
    against gram-negative bacterial endotoxins (septic shock（敗血症）)
   
 - Muromonab-CD3
    reversing acute renal allograft rejection (opsonization of T cells)
    side effect : flulike symptoms

 - Zolimomab aritox (monoclonal anti-CD5)
    treatment of steroid-resistant graft-versus-host disease after allogeneic bone marrow transpant
    treatment of rheumatoid arthritis & insulin-dependent diabetes mellitus

 - Betaseron (INF-β) ≒ INF-α
    treatment of multiple sclerosis(MS), AIDS, malignant melanoma（悪性黒色腫）, herpesvirus and papillomabirus infection
    side effect : flulike symptoms, bone marrow suppression, neurotoxic effects, anorexia（拒食症）, GI symptoms, hypohepatia, renal function↓


Today's question
- Biotechnologic product(バイオテクノロジー製品)の問題
Q: What drug is used to prevent embolism in the lung and during myocardial infarction
(A) Alteplase
(B) Human growth hormone
(C) Granulocyte-macrophage colony-stimulating factor
(D) Epogen(EPO)
(E) Non of the above





A: (A) Alteplase
Alteplase is a thrombolytic agent formerly known as tissue-lasminogen activator.